Best X399 Motherboard

The best gaming motherboard is smooth in overclocking modes, has maximum clearance, and expandable hierarchy for customization and upgrades. Before buying the best X399 motherboard for your AMD processor, make sure it has an expandable DDR4 RAM, HD audio support, and enough USB slots for connectivity.


Asus Rog Zenith

Best X399 Motherboard

  • For Games
  • MU-MIMO support
  • Powerfull



  • Ultra-Expandable
  • 4-Way Graphics
  • Powerful

GIGABYTE X399 Desig..

GIGABYTE X399 Designare EX (AMD Ryzen Thread Ripper

  • VR Ready
  • DDR4 Expandable
  • RGB Fusion 2.0

If you are looking for LED strips alongside a motherboard, make sure they are programmable and work flawlessly anywhere with all the components as well as your gaming system. An X399 motherboard is armed with armored PCIe ports, adjustable overclocking modes, and flawless cooling systems to meet up the heavy gaming demands by your system.

The best motherboards have high processor frequency and the latest connectivity cards and software. Make sure to buy the one with gold-plated connectivity ports, maximum clearance, and supplementary port acceptance whenever you need to upgrade the system. Make sure to double-check graphics card compatibility for your gaming needs before buying one. The ones with 5-way optimization are at a slight edge over the one without it, buy the one that fits the requirements and budget concurrently.

List of Best X399 Motherboard

NameAlready SoldRatingPricing
Asus Rog Zenith Extreme Alpha300+4.8
MSI Gaming AMD Ryzen ThreadRipper150+4.6
GIGABYTE X399 AORUS Xtreme80+4.8
GIGABYTE X399 Designare EX80+4.8

Asus Rog Zenith Extreme Alpha X399 HEDT

ASUS Rog Zenith extreme is a powerful machine for overclocking modes and compatible multi-player gaming. It hasAsus Rog Zenith Extreme Alpha X399 HEDT Gaming Motherboard everything that can fit the best x399 motherboard. There’s a 5-way optimization feature for auto-tuning and multi-fan support through FanXpert 4 overclock profiling. It will automatically switch to overclocking modes with the already programmed profiles.

The connectivity is enhanced to 802.11ac WiFi and onboard Aquantia 10G LAN with MU-MIMO support. The temperature and pressure sensors are coupled with FanXpert 4 along with the extremely accurate water cooling headers providing first-rate overall cooling.

Zenith Extreme possesses Aura sync dual RGB lighting headers for synced LED illumination and software support. The active heatsink features VRM fan, PCIe-zone aluminum casing for heat dissipation more subtly. The DDR4 memory can be expanded to 128GB at max and has a 3600 MHz frequency range for hardcore applications.

the performance is controlled and monitored through the AI suite 3 control display. The program can auto-tune any system component with a single click i.e. cooling, temperature charts, overclocking, and system efficiency. Supremefx headset output is made of powerful and noiseless sound deliverance via ESS hyper stream DAC architecture to make the sound more natural and balanced with dynamic output. Sound drivers are all built-in and customizable with Sonic Studio Software.

  • Perfectly made for hardcore gaming and overclocking
  • MU-MIMO support for connectivity
  • 128GB DDR4 expandable memory slots
  • Expensive and infeasible for medium-range gamers

MSI Gaming AMD Ryzen ThreadRipper

MSI gaming system is compatible with the Ryzen Threadripper processor and is compatible with all the hi-fi functions MSI Gaming AMD Ryzen ThreadRipper DDR4 VR Ready HDMIfor a powerful gaming PC. Backed with powerful DDR4 RAM compatibility of up to 128 GB, there’s nothing you can’t operate on a PC. The swappable heatsinks can be changed to any color for a better outlook.

The carbon-colored frame is completely insulated throughout the motherboard. It makes PC reliable and underheated through its cooling headers. Total fan control allows taking full control over your PC with a graphical interface. Set up to 4 cooling temperature thresholds for automatic overclocking and motherboard performance monitoring.

The audio functions are enhanced by MSI audio boost and premium-quality audio components making it the best sound delivery module overall in gaming PCs. X Boost app provides an intuitive GUI to get the best out of your motherboard.

  • GEN2 USB 3.1 slots
  • Synced RGB covers with 16.8 Million colors
  • DDR4 expandable memory up to 128GB
  • An expensive and complicated system
  • Clearance space lesser than usual

GIGABYTE X399 AORUS Xtreme (AMD Ryzen Thread

Gigabyte AORUS Xtreme is a beauty for gamers. It supports 2nd generation Ryzen Threadripper and 1st generation GIGABYTE X399 AORUS XtremeThreadripper processors. The design is in line with the fastest requirements by Threadripper processors. There’s booming audio with built-in drivers and crystal clear ESS Sabre Audio DAC, DDR4 memory capacity can be extended up to 128GB, and there’s a 4-way graphics support for the swift and sharp graphical interface when gaming solo or in multiplayer modes.

The connectivity is enhanced with the Dual Intel Gbe LAN along with 802.11ac WLAN and enhanced Internal Accelerator functions through Aquantia 10GbE LAN. The graphics card is supported by dual armor and triple thermal guards for safety and high-temperature endurance. For lighting lovers, RGB Fusion 2.0 LEDs lit with multiple lighting patterns and can completely sync with the system and components.

Gigabyte AORUS Xtreme supports 2nd generation USB 3.1 ports to the front with an array of heat sinks and thermal capacitors for enhanced protection. It has a durable NanoCarbon frame and I/O shield armors for longevity.

  • Supports the latest Ryzen processors
  • Ultra-expandable DDR4 memory
  • Powerful 4-way graphics and laudable network connectivity
  • Not available for Intel Core processors
  • Heavier than normal motherboards

ASUS ROG STRIX X399-E GAMING AMD Ryzen Threadripper

ASUS ROG is compatible with Ryzen X399 and all the other ThreadRipper TR4 processors of 1st and 2nd generation.ASUS ROG STRIX X399-E GAMING AMD Ryzen Threadripper TR4 DDR4 The E-Gaming motherboard is specifically designed for heavy gaming/overclocking without your components heating up in the middle. It is made of expandable RAM slots, up to 128GB with DDR4 compatibility. The 5-way optimization integrates auto-tuning and cooling via FanXpert 4, it allows to create personal profiles for overclocking modes and adapts cooling mode automatically whenever a system is overclocked.

There are secure PCIe slots with armored protection and safe slots with support of the injection molding process. RGB embedded lighting can be personalized and synced through ASUS Aura LEDs. Customize your lighting patterns or sync them with the system with the personal RGB profiling from your gaming PC.

The audio quality is made crisp and calm with 8-channel HD audio and exclusive SupremeFX capacitors comprising Japanese capacitors for durable working. Enjoy uninterrupted Internet via 802.11ac WiFi, expand connectivity with 2nd generation USB 3.1 ports with 2x speed and more connectivity options than the rest.

  • Compact and ergonomic design
  • 5-way optimization included
  • Features 8-channel HD Audio
  • DDR4 expandable memory
  • Consumes more power from the system
  • Not compatible to Intel Processors

GIGABYTE X399 Designare EX (AMD Ryzen Thread Ripper TR4/ATX

Gigabyte supports Ryzen X399 thread ripper processors, they are compatible for heavy gaming and overclocking GIGABYTE X399 Designare EX (AMD Ryzen Thread Rippermodes with expandable DDR4 memory up to 128GB, rear, and front USB slots, and a high-performing network connection for uninterrupted WiFi and ethernet via 802.11 a/b/g/n/ac with support of 2.4GHz & 5GHz dual-band connectivity.

The power connectors are integrated into the system via gold plating and server-class digital power design hierarchy. RGB Fusion 2.0 provides synced lighting with gaming PC with already-integrated LED strips and lights shows of your choice.

Gigabyte Designare EX has triple ultra-fast M.2 with PCIe slots and armored protection; the USB DAC-UP 2 can be adjusted automatically as per the required voltage. Designare EX is virtual reality ready and has maximum power endurance up to 250W, it can expand to about 48 ports with an intuitive PCI express design. Play games on your workstation, overclock, and modify your X399 threadripper processor, play with the lighting system via PC, and connect to 3 screens at a time for expanded gaming impeccably.

  • Dual-band connectivity for Wi-Fi
  • RGB Fusion 2.0 synced lighting compatibility
  • VR ready
  • Quad-channel DDR4 expandable RAM
  • Only supported to AMD Ryzen processors
  • Overpriced and overhyped